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JWH-018 is considered a well-known cannabinoid. Its popularity has make the level of Marijuana down. For high experience, people use this drug the most.

JWH -018 ( 1-pentyl-3-(1-naphthoyl)indole ) or AM-678 2 is a naphthoylindole psychotropic analgesic that acts as a full agonist of the cannabinoid receptors  (in) ( Cannabinoids ) CB 1 and CB 2 , with some selectivity for the CB 2 receptor . 

In animals, it produces effects similar to those of tetrahydrocannabinol (THC), a cannabinoid found naturally in cannabis, leading to its use in synthetic cannabis products, labeled "not for human consumption

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John W. Huffman , a Clemson University chemist , synthesized a large number of chemical compounds that affect the endocannabinoid system , including JWH-018. 

Studies show an affinity for the CB 1 cannabinoid receptor five times greater than that of THC. Cannabinoid receptors are found in mammalian brain and spleen tissue ; however, the detailed structure of the active sites is currently unknown 8 .

LeDecember 15, 2008, the German pharmaceutical company THC Pharm reported that JWH-018 was one of the active ingredients of at least three versions of the herbal mixture Spice , sold as incense in several countries since 2002 9 , 10 , 11 , 12 . Analysis of samples acquired four weeks after JWH-018 was banned in Germany revealed that the compound had been replaced by JWH-073

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The metabolism of JWH-018 was studied in Wistar rats administered an ethanolic extract containing JWH-018. Urine was collected for 24 hours, then JWH-018 metabolites were extracted using liquid-liquid extraction and solid-phase extraction . 

The extracted compounds were separated and identified with GC-MS. JWH-018 and its N-dealkylated metabolite were only detected in small amounts, with the hydroxylated N-dealkylated metabolites comprising the primary signal. 

The observed mass discrepancy indicates that hydroxylation is likely to occur in both the naphthalene and indole portions of the molecule 15. 

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The human metabolites were similar, although most metabolism took place on the indole ring and the pentyl side chain, and the hydroxy metabolites were highly conjugated to the glucuronide

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