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April 29, 2022

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MDPV Powder (Methylenedioxypyrovalerone) is a stimulant of the cathinone class which acts as a Norepinephrine–dopamine reuptake inhibitor (NDRI). It was first developed in the 1960s by a team at Boehringer Ingelheim.

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Its activity at the dopamine transporter is six times stronger than at the norepinephrine transporter and it is virtually inactive at the serotonin transporter.

MDPV Powder remained an obscure stimulant until around 2004 when it was reportedly sold as a designer drug.

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Until banned in 2011, products containing MDPV Powder and labeled as bath salts were sold as recreational drugs in gas stations and convenience stores in the United States, similar to the marketing for Spice and K2 as incense.

Methylenedioxypyrovalerone ( MDPV ) is a highly addictive psychostimulant drug from the cathinone family .

It was first developed in the 1960s by a team from Boehringer-Ingelheim 4 . It had since remained an unknown compound until it was popularized from 2004 under the name "bath salts" or sold as a new synthetic product ( research chemical ).

It is chemically related to pyrovalerone , a stimulant drug discontinued due to its significant abuse potential

The pharmacology of MDPV is relatively little known and explored.

However, it appears to act, similar to other stimulants such as cocaine, amphetamine and most molecules belonging to the cathinone family (including pyrovalerone analogues), as a reuptake inhibitor dopamine and norepinephrine.

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However, it differs from other synthetic cathinones by the presence of a pyrrolidine ring which gives it its power to inhibit the uptake of catecholamines by their transporters 5 , but also by an action on the elimination of dopamine, at like cocaine

It has an extremely high abuse potential, which has been observed in rats and humans

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